乐虎游戏

ZHANGYUYANJIUZUJIESHIXIJUNClass IIIZHUANLUJIHUOJIZHI

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  2020NIAN9YUE28RI,Nature Chemical Biology ZAIXIANFABIAOLEZHONGGUOKEXUEYUANFENZIZHIWUKEXUEZHUOYUECHUANGXINZHONGXINHECHENGSHENGWUXUEZHONGDIANSHIYANSHIZHANGYUYANJIUZUTIWEI“CueR activates transcription through a DNA distortion mechanism”DEYANJIULUNWEN。GAILUNWENZHUYAOYANJIULEXIJUNClass IIIZHUANLUYINZICueRZHUANLUJIHUODEFENZIJIZHI。

乐虎游戏  DAYUE50NIANQIAN,FAGUOZHUMINGKEXUEJIAJacobHEMonodFAXIANRUTANGCAOZONGZI,SHOUCITICHUJIYINBIAODASHOUDAODANBAIDIAOKONG。ZUEDANBAILac IHEDAIXIEWUJIHUODANBAICRP (cAMP receptor protein; YEBEICHENGWEIcatabolite activator protein, CAP )JINJIEZHEBEIZHENGMINGNENGGOUZHIJIEJIEHERUTANGCAOZONGZI,FENBIEFAHUIZHUANLUYIZHIHEZHUANLUJIHUODEGONGNENG。SUIHOUDAJIADUIZHUANLUYINZIRUHEYIZHIYIJIJIHUOZHUANLUFASHENGLENONGHOUDEXINGQU。DAYUE30NIANQIAN,Thomas A. SteitzYANJIUZUJIEXILECAP/CRPYUDNADEFUHEWUJINGTIJIEGOU,GAIJIEGOUSHOUCIZHANSHILEZHUANLUYINZISHIBIEDNADEFANGSHI。ZAISUIHOUDEJISHINIANZHONG,KEXUEJIAMENLIYONGHUAXUEJIAOLIAN、DNAZUJI、YICHUANTUBIANDENGFANGFACHANGSHILEJIEZHUANLUYINZIDIAOKONGJIYINZHUANLUDEJUTIJIZHI,DAJIAFAXIANZHUANLUYINZIZAIQIDONGZIDNADEJIEHEWEIZHIZHIJIEJUEDINGLEQIDUIYUXIAYOUJIYINDEYINGXIANG,YIBANLAIJIANG,ZHUANLUYINZIJIEHEZAIHEXINQIDONGZIQUYU(-35QUHE-10QU)SHANGYOUFAHUIZHUANLUJIHUOGONGNENG,ZHUANLUYINZIJIEHEZAIHEXINQIDONGZIQUYUHUOZHEJIYINNEIBUZEYIZHIZHUANLU。ERZHUANLUJIHUOANZHAOZHUANLUYINZIJIEHEWEIDIANJULIHEXINQIDONGZIQUYUYUANJINYOUFENWEILIANGLEI,JIEHEWEIDIANWEIYUQIDONGZIHEXINQUYUSHANGYOUWEIDIYILEIZHUANLUJIHUO(Class I),ERJIEHEWEIDIANYUQIDONGZIHEXINQUYUSHAOYOUZHONGDIECHENGWEIDIERLEIZHUANLUJIHUO(Class II)。ZHIDAO2016NIANHE2017NIAN,Richard H. EbrightHEThomas A. SteitzYANJIUZUYICAPWEIMOXING,ZAIScienceZAZHISHANGBAODAOLEXIJUNClass IYUIIZHUANLUJIHUOYINZIYURNAJUHEMEIYIJIQIDONGZIDNADEFUHEWUJIEGOU,JIESHILEJINGDIANDEZHUANLUJIHUOFENZIJIZHI。ZONGTILAISHUO,TAMENTONGGUODNAJIEHEJIEGOUYUYUQIDONGZIDNAXIANGHUZUOYONG,TONGGUOQIZHUANLUJIHUOJIEGOUYUYURNAJUHEMEIXIANGHUZUOYONG,JIANGRNAPJUHEMEIFUJIDAOQIDIAOKONGDEQIDONGZIDNAQUYUJIHUOZHUANLU。

  ZAITANSUOCAPZHUANLUJIHUOJIZHIDETONGSHI,David C. FritzingerFAXIANLEYIZHONGJIZHITEYIDEZHUANLUYINZIMerR,TANENGGOUJIEHEZAINAIGONGJIYINCUQIDONGZIHEXINQUYU,YURNAPDEJIEHEWEIZHIWANQUANZHONGDIE,ZAIYIBANQINGKUANGXIAYIZHIXIAYOUJIYINBIAODA,ERBAONEIGONGLIZINONGDUGAOSHI,ZEJIHUOXIAYOUJIYINBIAODA。ZHEIZHONGXIANXIANGYUSHANGSHUClass IHEClass IIDEZHUANLUJIHUODIAOKONGFANGSHIWANQUANXIANGBEI,YINWEIMerRDEJIEHEWEIZHIYURNAPJIEHEWEIZHIWANQUANZHONGDIE,ANZHAOZHIQIANDEGUILVQIYINGGAIZHIFAHUIZHUANLUYIZHIGONGNENG,BINGQIEMerRDIAOKONGDEJIYINQIDONGZIDNADE-35QUHE-10QUJIANGEWEI19bp,ERXIJUNRNAJUHEMEIZHINENGSHIBIE-35QUHE-10QUJIANGEWEI17±1DEQIDONGZI。SUIHOUDAJIAZAIHENDUOXIJUNZHONGDOUFAXIANLEGAILEIZHUANLUYINZIDECUNZAI,YUSHIZHEILEIDANBAIBEIMINGMINGWEIMerRJIAZUZHUANLUYINZI,TAMENNENGGOUGANSHOUBAONEIDEJINSHULIZI、YANGHUAZHUANGTAIYIJIKANGSHENGSUXIEPO。CONG20SHIJI90NIANDAIKAISHI,DAJIALIYONGDNAZUJISHOUDUAN,FAXIANMerRCHUYUYIZHITAIHEJIHUOTAISHI,QIJIEHEDEQIDONGZIDNAGOUXIANGKENENGYOUJIAODADEGOUXIANGBIANHUA。Thomas V. O’ HalloranYANJIUZUZHENDUIMerRJIAZUDANBAIJINXINGLEDALIANGDEJINGTIJIEGOUYANJIU,TAMENCONG2003DAO2015NIANFENBIEJIEXILECueR apo protein, CueR-DNAERYUANFUHEWU,YIJICueR-Ag+-DNASANYUANFUHEWUDEJINGTIJIEGOUJIEXI,CHANMINGLEGAIJIAZUCHENGYUANZAIBUJIEHEPEITISHI,JIEHEBIAOZHUNDEBXINGSHUANGLIANDNA,ERJIEHEPEITIHOU,NENGGOUSHIBXINGSHUANGLIANDNAFASHENGYUE90DUDEWANZHE,SHIQIJUBUQUYUCHENGXIANAXINGSHUANGLIANDNADEGOUXIANG。ZHEIWEIGAILEIZHUANLUYINZIDEJIHUOJIZHIGENGJIAZENGJIALEYICENGSHENMIDEMIANSHA。JIANYUQIZHUANLUDIAOKONGFANGSHIDETESHUXING,DAJIAJIANGMerRJIAZUZHUANLUJIHUOFANGSHIMINGMINGWEIFEIDIANXINGDEZHUANLUJIHUOHUOZHEClass IIIZHUANLUJIHUO。

  WEILEJIESHIMerRJIAZUZHUANLUYINZIDEZHUANLUJIHUOJIZHI,ZAIGAILUNWENZHONG,ZUOZHEYIDACHANGGANJUNZHONGGANYINGYINLIZIHEYATONGLIZIDECueRDANBAIWEIDUIXIANG,JIEXILECueR、Ag+、QIDONGZIDNAYIJIRNAJUHEMEIDEZHUANLUJIHUOFUHEWUDIANJINGJIEGOU。JIEGOUXIANSHICueRJIEHEZAIQIDONGZIDNADELIANGGEGUANJIANQUYU-35QUHE-10QUZHIJIAN,SHISHUANGLIANDNAZAISIGEWEIZHIFASHENGLEJIAODACHENGDUWANZHE,TEBIESHIWEIYUCueRERJUTIZHONGXINDEWEIZHI,DNAFASHENGLEYUE90DUDEWANQU。ZHEIZHONGYOUCueRJIEHEDAOZHIDEQIDONGZIDNAWANQU,SHI 19bpDE-35/-10JIANGEQUYUZHONGXINYASUODAOLE17bpDEWULIJULI,CONGERSHIRNAJUHEMEINENGGOUCHENGGONGQIDONGXIAYOUJIYINZHUANLU。LINGWAI,GAIFUHEWUJIEGOUXIANSHISUIRANCueRZAIQIDONGZIDNASHANGDEJIEHEWEIDIANYURNAPJUHEMEIDEJIEHEWEIDIANWANQUANZHONGDIE,DANSHICueRJIEHEZAIQIDONGZIDNADEYICE,ERRNAPJIEHEZAIQIDONGZIDELINGYICE,CueRYURNAJUHEMEIMEIYOUXIANGHUZUOYONG,ERZHEHUBUGANRAO,ERZHEIYIDIANYEYUClass IYIJIClass IIDEZHUANLUJIHUOJIZHIWANQUANBUTONG。ZUIHOU,GAIYANJIUJIEXILEYICueRWEIDAIBIAODEXIJUNClass IIIZHUANLUJIHUOFUHEWUJIEGOU,JIESHILEGAILEIZHUANLUJIHUODANBAIBUYILAIYURNAJUHEMEIDEXIANGHUZUOYONG,JINTONGGUOGAIBIANDNAGOUXIANGJIHUOZHUANLUDEFENZIJIZHI。

  LUNWENDIYIZUOZHEWEIZHANGYUYANJIUZUBOSHISHENGFANGCHENGLIHEMEIGUOXIBEIDAXUE(Northwestern University)Steven J. PhilipsBOSHI。ZHEJIANGDAXUEYIXUEYUANFENGYUYANJIUYUAN,MEIGUOXIBEIDAXUEThomas V. O’HalloranJIAOSHOUYIJIZHANGYUYANJIUYUANSHIGAILUNWENDETONGXUNZUOZHE。GANXIEZHEJIANGDAXUEDIANJINGZHONGXINYIJIGUOJIADANBAIZHIZHONGXIN(SHANGHAI)DUIYUBENKETIDEDALIZHICHI,TEBIESHIGANXIEDANBAIZHONGXINZAIYIQINGQIJIANPIZHUNDEJINJIDIANJINGJISHIYUKONGLIANGLIANGLAOSHIHEWANGFANGFANGLAOSHIZAIYIQINGQIJIANDUILEHUYOUXISHUJUSHOUJIDEBANGZHU。GAIYANJIUSHOUDAOGUOJIAZIRANKEXUEJIJIN、ZHONGKEYUANXIANDAOBYIJISHANGHAISHIKEJICHUANGXINXINGDONGJIHUADEZIZHU。

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